Selected Achievements:
* Worked as Co Investigator in the University minor research project titled “1,2,4-triazoles as non ulcerogenic non steroidal anti
inflammatory agents”.
* Worked as Senior Research Fellow (CSIR, New Delhi), from 1st July 1995 to 31st Jan., 1998.
The following class of compounds have been prepared:
1. 2-Substituted-3H-thiazolo(2,3-b)-8-aryl pyrazolo(4,3-c)pyrimidin-5-ones;
2. 5H-Thiazolido(3,2-a)-8-(4-substituted phenyl/benzoyl)-pyrazolo(4,3-e)-4-(4-substituted phenyl pyrimidinyl-1,5-diones;
3. 2-(N,N-Dialkylamino/piperidino/morpholino)ethyl-7-halothiazolo(2,3-b)quinazolino-5-ones;
4. 2-(4-OH/l/N,N-dimethyl amino)phenyl-3-β-[(N-benzene sulphonyl/tosyl)-4-(substituted anilino]propionyl amido-1,3-thiazolidin-4-ones;
5. 1- β-[(N-Benzene sulphonyl/tosyl)-4-(substituted anilino]propionylamido–3-chloro-4-(OH/N,N-dimethyl amino)phenyl azetidin -2-ones.
* At Innovassynth, Khopoli :
Nature of work : working on the synthesis and functional group transformations of Nucleosides and Nucleotides (especially functional group transformations like – Omethylation, -O-TBDMSilylation, -O-tritylation, N-i-butyralation, TIPDSillation, -O-TBDMSilylation, -O-tritylation, N-i-butyralation, TIPDSillation, TMCS-protections, ditriflate protection followed by deprotections [by using HFPyridine, HF-TEA and TEAF (Tetra ethyl ammonium fluoride)] etc. (Worked for the projects of ISIS, GERON CORPN., HONEYWELL, RPI & many other US companies).
Following are the few projects :
5’- ODMT-2’-OMe-N2- Bui-Guanosine- (starting from 2,6,diamino purine),
5’- ODMT - 2’-TBDMS-N2-isobutyryl-Guanosine- starting from Guanosine) .
triethyl ammonium salts of (N-Bz-5-Me-5’-ODMT-dC; 5’-ODMT-T,
N-Bz-5’-ODMT-dG; N-Bz-5’-ODMT-dA - succinoyl)
Major Projects completed successfully : Worked on a major project of GERON
Corporation, USA. (up to 1.0 Kg Sample):
1. 3’-Trityl amino-2’-deoxy thymidine-5’-(2-cyanoethyl ethyl, N-N,-diisopropyl) Phosphoramidite;
2. 3’-Trityl amino-N-Benzoyl- 2’-deoxy -5’-(2-cyanoethyl ethyl, N-N,-diisopropyl) Phosphoramidite;
3. 3’-Trityl amino-N2-iBu-2’-deoxy guanosine-5’-(2-cyanoethyl ethyl, N-N-diisopropyl) Phosphoramidite;
4. 3’-Trityl amino-N-Bz- 2’-deoxy adenosine-5’-(2-cyanoethyl ethyl, N-N-diisopropyl) Phosphoramidite;
* At Syngene International Limited, B'lore:
Nature of work : Worked on the synthesis of drug intermediates, fine chemicals
(for Affymax, Serono Pharmaceuticals, Astra-Zeneca etc., in the form of Contract
Research) and successfully completed the following projects:
1 : N-Flourenyl methoxy carbonyl (Fmoc)-4-allyloxy carbonyl amino (alloc)-Cis
(& trans) -D (& L)-prolines;
2 : [2-(N-benzenyloxy carbonyl (CBZ)-2,3-dimethoxy)pyrrolidinyl] ethanol;
3 : 2-phenyl-pyridine-5-carboxylic acid and its N-oxide;
4 : 3-(4-hydroxy phenyl)benzotriflouride;
5 : 4-(4-hydroxy phenyl)benzotriflouride;
6: 4-(4-hydroxy phenyl)-1-n-butyl benzene and
7 : 4-(4-hydroxy phenyl)-1-t-butyl benzene;
* At Rallis India Limited, Mumbai :
Nature of work : Worked on the synthesis of Agrochemicals (newly patented compounds) such
as Fungicides, Herbicides, Plant Growth regulators, Insecticides and Pesticides : Successfully
completed the following projects:
a : Trifluralin : (2,5-dinitro-4-triflouromethyl)-N,N-dipropyl aniline;
b: SLA-5599 : {1-2,6-dichloro-4-diflouromethyl)phenyl-4-nitro-5-(2-chloro-5-propionylamido)-pyrazole – (both herbicides; upto pilot plant level) and
c: Tolyfluanid : ( N -dichloroflouromethylthio- N,N- dimethyl-N- p-tolyl sulphamide (a fungicide) - (up to 1.0 Kg in all three projects).
Various reactions carried out:
Hydrazination, Micheal Addition (under pressure-autoclave) ; Mannich reaction; Hydrogenation (using Pd/C under a pressure of 24 Kg autoclave), Suzuki – coupling ; Omethylation; N-isobutyrylation, TIPDS (and dibutyl silyl ditriflate ) protection of 1,2-diols (nucleosides)- followed by de protections using HF-TEA, HF-Pyridine; O-dimethoxy tritylation; N-isopropylation; nitration (using fuming nitric acid-fuming sulfuric acids – acyl nitrate) ; Reduction; Cyanation (using Sodium cyanide); proline (D & L- Cis _trans)-derivatives (esterification, desylation, cyanide condensation, ester hydrolysis, hydrogenation, N-BOCpreparation; N-Fmoc preparation),O-TBDMsylilation etc.
Heterocyclic compounds: 1,2,4-triazoles; 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, pyrazolo-pyrimidine derivatives; -s-triazolo(3,4-b)(1,3,4)thiadiaoles, -s-triazolo(3,4-b)(1,3,4)thiadiazines, -s-triazolo(3,4-b)(1,3,4)thiadiazinones; -s-triazolo- (3,4-b)(1,3,4)benzothiadiazines; -s-triazolo(3,4-b)(1,3,4)thiadiazepines.